Memphis to New Orleans · and Beyond

Where to Stay
Along the Way

A hospitality guide to the entire Big Muddy corridor. Eighteen cities, five states, and the best places to lay your head — from haunted plantations to artists’ lofts, juke-joint motels to grand hotels.

Book the Inn in Natchez
Big Muddy Prevost tour bus on a Southern road
Cities18Across five states
States5TN · MS · LA · AR · MO
Properties40+Curated lodging picks
Home BaseNatchezThe Big Muddy Inn

The Big Muddy Inn & Blues Room

411 N Commerce Street, Natchez, Mississippi. Six suites, each named for a legend of American music. This is where the Big Muddy started — and where every route begins and ends. The property details, suite descriptions, and booking are at the dedicated inn site.

Visit thebigmuddyinn.com
The Big Muddy Inn foyer

The Core Corridor

Memphis to New Orleans — the headline run. Five cities along the Mississippi where the music started and never stopped.

Memphis, TN

The birthplace of rock and roll, soul, and the blues

Historic grand hotel since 1869, National Register of Historic Places. Watch the daily duck march, then walk to Beale Street.

ARRIVE Memphis

From $250/night

Stylish modern boutique celebrating local artists and Memphis soul. Steps from South Main Arts District.

1848 Victorian mansion turned luxury B&B. National Historic Landmark with opulent suites and original millwork.

Clarksdale, MS

The crossroads of the Delta blues

Shack Up Inn

From $65/night

Renovated sharecropper shacks on Hopson Plantation. "Bed & Beer" with live blues and authentic Delta grit.

Clark House Inn

From $75/night

Historic 1859 home of Clarksdale founder John Clark. Walking distance to every blues site that matters.

Travelers Hotel

From $100/night

Artist-run boutique in a restored downtown building. Community hub for creatives passing through the Delta.

Vicksburg, MS

Antebellum mansions and battlefield ghosts

Grand 1830s antebellum mansion with pool, gardens, and on-site restaurant. Southern Gothic hospitality at its finest.

1850s antebellum mansion, once a Civil War hospital. Period furnishings, daily 3-course breakfast, and yes — it is haunted.

1910 Mission Revival mansion with 32 original stained glass windows and a dedicated Delta Blues Room.

Natchez, MS

Where the river bends south toward New Orleans

Our home base. Six suites, each named for a legend. 411 N Commerce Street, in the oldest part of town, perched above the bluff.

National Historic Landmark antebellum mansion on 26 acres of gardens. Luxury lodging steeped in another century.

Elegant 1893 Queen Anne Victorian B&B with gourmet breakfasts and lush gardens.

New Orleans, LA

The city that never needed an introduction

Hotel Monteleone

From $250/night

French Quarter landmark since 1886. The Carousel Piano Bar rotates — literally. Tennessee Williams drank here.

Hotel Peter and Paul

From $200/night

Converted 19th-century church, school, and convent in Marigny. Stained glass, cloistered courtyards, speakeasy bar.

Boutique hotel with haunted bordello history. Saltwater pool, central French Quarter, and more ghosts than guests.

Big Muddy Tesla in downtown Lafayette
Azaleas cascading along Natchez sidewalkVictorian B&B with wraparound porchBrick sidewalk with awnings in Natchez

Louisiana Network

Bayou country, Cajun heartland, and the pine-hill towns of the north. Eight cities with hospitality that runs deeper than the roots.

St. Francisville, LA

Haunted plantations and mossy oaks

Famed haunted antebellum plantation from 1796. Ghost tours, Gothic gardens, and rooms where the past never left.

Luxurious boutique in a renovated 19th-century home. Spa, pool, and a central historic district perch.

Baton Rouge, LA

State capital, riverfront, and LSU's purple pulse

WATERMARK Baton Rouge

From $170/night

Luxe boutique inside a restored 1927 bank. Marble, soaring interiors, and a prime downtown riverfront location.

Historic B&B with a quiet, residential setting. Porches, gardens, and a personal Baton Rouge experience.

Lafayette, LA

Capital of Cajun country

T'Frere's House

From $190/night

Acadian-style B&B in a preserved 1880 home. True Cajun hospitality, full breakfasts, and gardens under ancient oaks.

AAA 4-Diamond boutique all-suite hotel. Southern charm meets luxury in River Ranch.

Alexandria, LA

Gilded Age elegance at the crossroads of Louisiana

Hotel Bentley

From $100/night

Historic 1908 Gilded Age hotel with grand Ionic columns and a lobby that hosted WWII generals.

Susan's Cottages

From $200/night

Private romantic cottages in a pecan orchard along Bayou Rapides. Whirlpool tubs and bayou-view balconies.

Monroe, LA

Ouachita River honky-tonk and Southern soul

The Hotel Monroe

$$–$$$

Boutique stay in restored 1891 buildings with local art throughout. Downtown, walkable to everything.

Hamilton House Inn

$$–$$$

Luxury B&B in Antique Alley with rooftop terrace overlooking West Monroe.

Ruston, LA

Pine-hill college town with indie roots

The Big House

$$–$$$

Historic downtown venue with luxurious king suites blending antebellum echoes and modern comfort.

Ruston Lofts

$$–$$$

Micro-boutique hotel in a restored 1920s department store. Minimalist suites with industrial charm.

Natchitoches, LA

The oldest settlement in Louisiana

Downtown boutique with French Quarter-inspired courtyard. Brick, fountain, old-world lobby.

Sweet Cane Inn

From $130/night

Restored Victorian B&B with high ceilings, fireplaces, stained glass, and a standout breakfast.

Shreveport, LA

Speakeasies, Victorian porches, and the Red River

Downtown all-suite boutique in a 100-year-old building. 1920s speakeasy vibe on the rooftop.

2439 Fairfield B&B

From $150/night

Circa-1905 Victorian mansion packed with antiques and gardens. Pure Southern Gothic on Fairfield Avenue.

Live oak canopy over Ocean SpringsShrimp boat at Ocean Springs marinaAntebellum mansion with iron fence

Arkansas & Missouri

Ozark hollows, art trails, and mountain music. The northern reach of the Big Muddy network — where the river begins to feel different.

El Dorado, AR

Oil boom town turned arts district

The Haywood

From $150/night

Boutique hotel in the heart of Murphy Arts District. Modern comfort meets historic Southern charm.

Pinson House B&B

From $100/night

Circa 1919 historic B&B two blocks from the square. Full breakfast and small-town warmth.

Little Rock, AR

State capital with civil rights history and a raw music scene

Capital Hotel

$$$

Gilded Age luxury downtown. The kind of grand Southern hotel that makes you slow down.

The Empress of Little Rock

$$–$$$

Victorian B&B with ornate period charm. A queen of a house.

Fayetteville, AR

Ozark college town where Dickson Street never sleeps

Inn at Carnall Hall

From $148/night

Historic University of Arkansas dorm turned boutique hotel. Campus charm meets refined hospitality.

Pratt Place Inn

From $234/night

Luxury B&B on a wooded estate. Privacy, porches, and Ozark quiet.

Bentonville, AR

Trails, art, and unexpected culture

21c Museum Hotel

$$$

Artsy boutique with contemporary exhibits in every hallway. Sleep surrounded by art, ride trails in the morning.

The Victoria B&B

From $200/night

Victorian charm adjoining Crystal Bridges Museum. Walk to the art, walk to the square.

Branson, MO

Ozark variety shows and fog-shrouded hollows

Carriage House Inn

$$–$$$

Victorian-style inn near the Strip. Southern hospitality meets Ozark mountain charm.

Bradford House B&B

$$–$$$

Elegant Victorian downtown. A quieter Branson, away from the neon.

The Big Muddy Inn, Natchez

Six suites. Live blues downstairs. The Mississippi around the corner. This is where it all starts.

Book at thebigmuddyinn.com